Université McGill, 4 - 7 décembre 2015
Joint work with Florence Véronneau-Veilleux.
This is a project from the Development of an Antimicrobial Resistance Diversity Index (ARDI) led by Prof. Jianhong Wu.
However, the suitability of this NCA approach is questioned for complex drug eliminations, as it is the case for simultaneous first-order and Michaelis-Menten eliminations.
In this talk I will discuss two indistinguishable PK models having a structure of two compartments and different elimination pathways.
As results I will show the corresponding exact model based expressions of Vdss directly derived from its physiological definition and discuss their relationship to the NCA counterparts. As proof of concept, the important difference will be shown on various real drug models.
Moreover, considering the issue of model identifiability, the evaluation of Vdss will be discussed.
This is a joint work with X.T. Wu and F. Nekka
Joint work with Joel Dubin and Kamal Rai, University of Waterloo.