Let $H$ be a separable, infinite-dimensional, complex Hilbert space and let $A, B\in{\mathcal L }(H)$, where ${\mathcal L}(H)$ is the algebra of all bounded linear operators on $H$. Let $\delta_{AB}\colon {\mathcal L}(H)\rightarrow {\mathcal L}(H)$ denote the generalized derivation $\delta_{AB}(X)=AX-XB$. This note will initiate a study on the class of pairs $(A,B)$ such that $\overline{{\mathcal R}(\delta_{AB})}= \overline{{\mathcal R}(\delta_{A^{\ast}B^{\ast}})}$.