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1. CJM 2003 (vol 55 pp. 3)
| An Exactly Solved Model for Mutation, Recombination and Selection It is well known that rather general mutation-recombination models can be
solved algorithmically (though not in closed form) by means of Haldane
linearization. The price to be paid is that one has to work with a
multiple tensor product of the state space one started from.
Here, we present a relevant subclass of such models, in continuous time,
with independent mutation events at the sites, and crossover events
between them. It admits a closed solution of the corresponding
differential equation on the basis of the original state space, and
also closed expressions for the linkage disequilibria, derived by means
of M\"obius inversion. As an extra benefit, the approach can be extended
to a model with selection of additive type across sites. We also derive
a necessary and sufficient criterion for the mean fitness to be a Lyapunov
function and determine the asymptotic behaviour of the solutions.
Keywords:population genetics, recombination, nonlinear $\ODE$s, measure-valued dynamical systems, Möbius inversion Categories:92D10, 34L30, 37N30, 06A07, 60J25 |

