Let $\cal H$ be a complex separable Hilbert space and ${\cal L}({\cal H})$ denote the collection of bounded linear operators on ${\cal H}$. An operator $A$ in ${\cal L}({\cal H})$ is said to be strongly irreducible, if ${\cal A}^{\prime}(T)$, the commutant of $A$, has no non-trivial idempotent. An operator $A$ in ${\cal L}({\cal H})$ is said to a Cowen-Douglas operator, if there exists $\Omega$, a connected open subset of $C$, and $n$, a positive integer, such that (a) ${\Omega}{\subset}{\sigma}(A)=\{z{\in}C; A-z {\text {not invertible}}\};$ (b) $\ran(A-z)={\cal H}$, for $z$ in $\Omega$; (c) $\bigvee_{z{\in}{\Omega}}$\ker$(A-z)={\cal H}$ and (d) $\dim \ker(A-z)=n$ for $z$ in $\Omega$. In the paper, we give a similarity classification of strongly irreducible Cowen-Douglas operators by using the $K_0$-group of the commutant algebra as an invariant.