We establish asymptotics for Christoffel functions associated with multivariate orthogonal polynomials. The underlying measures are assumed to be regular on a suitable domain - in particular this is true if they are positive a.e. on a compact set that admits analytic parametrization. As a consequence, we obtain asymptotics for Christoffel functions for measures on the ball and simplex, under far more general conditions than previously known. As another consequence, we establish universality type limits in the bulk in a variety of settings.